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Master Thesis

Le baclofène à haute dose : effet sur la consommation d’alcool et de psychotropes chez 219 patients de médecine générale suivis rétrospectivement 3 ans

Abstract : Introduction: Available approved treatments for the care of alcohol dependence are not effective enough over time; high-dose baclofen could be an alternative therapeutic. It could also be used as an anxiolytic and/or an antidepressant. Objective: Evaluation of the impact of a high-dose baclofen treatment on alcohol and psychotropic drugs use in outpatients taken care of for alcohol disorders. Materials and methods: Descriptive retrospective cohort of 219 patients followed during 3 years by a general practitioner and treated with high-dose baclofen in order to reduce or stop their alcohol use. Results: The population for this study included 134 men and 85 women, with an average age of 46 ± 11 years, and the average daily alcohol dose amounted to 164 ± 93 grams. After 1 year, 182 patients were still followed and 61,5% of them were abstinent or had a low-risk use (≤ 40 g/d for men and ≤ 20 g/d for women). After 2 years, 156 patients were still followed and 63,7% of them were abstinent or had a low-risk use. After 3 years, the proportion amounted to 61,8% among the 144 patients who were still followed. Among followed patients, there was no significant trend towards the decrease of psychotropic drugs. Conclusion: Baclofen appears to be an effective and long-term treatment in the care of alcohol disorders. The results of the randomized, controlled, double-blind studies should confirm our observations.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01302494
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Submitted on : Thursday, May 19, 2016 - 10:01:15 AM
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  • HAL Id : dumas-01302494, version 1

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Juliette Pinot. Le baclofène à haute dose : effet sur la consommation d’alcool et de psychotropes chez 219 patients de médecine générale suivis rétrospectivement 3 ans. Médecine humaine et pathologie. 2015. ⟨dumas-01302494⟩

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