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Master Thesis

IRM de perfusion et TEP-TDM avant chimiothérapie néoadjuvante pour prédire la réponse histologique des cancers du sein

Abstract : Purpose: To evaluate DCE-MRI and PET-CT at baseline for prediction of pathological response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer. Materials and methods: 88 patients with locally advanced breast cancer treated with NAC followed in DCE-MRI at 1.5T and PET-CT were included in this retrospective study. Perfusion parameters (Ktrans, kep, ve) and SUVmax were measured at baseline of the NAC. Imaging datas were compared with tumoral and nodal pathologic response, prognostic factors (histologic grade, expression of hormonal receptors, human epidermal growth factor receptor 2, p53 and Ki-67) and subtypes of breast cancers. Results: Response were observed in 54 patients (61%) and non-response in 34 patients. Low ve and high SUVmax were significatively associated with tumoral response to NAC (ve, p=0,0035 ; SUVmax, p=0,0265). Other perfusion parameters were not significatively associated to pathological response. Low ve was significantly associated with high histologic grade (SBR III), negative estrogen receptor, p53 muted and Ki67 >15%). Triple negative cancers showed a lower ve than other subtypes. High SUVmax was significantly associated with high histologic grade (SBR III) and p53 muted. Triple negative and HER2 subtypes showed a higher SUVmax than the luminal type. Conclusion: ve and SUVmax before NAC were associated with tumoral response and histopathological aggressivity markers.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01305983
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Submitted on : Friday, April 22, 2016 - 10:23:15 AM
Last modification on : Friday, March 27, 2020 - 2:19:22 AM
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  • HAL Id : dumas-01305983, version 1

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Loïc Colleter. IRM de perfusion et TEP-TDM avant chimiothérapie néoadjuvante pour prédire la réponse histologique des cancers du sein. Médecine humaine et pathologie. 2015. ⟨dumas-01305983⟩

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