Statut vitaminique C chez des sujets hospitalisés dans un service de médecine interne : analyse de fréquence, facteurs de risque et corrélation clinico-biologique

Abstract : Regular cases of scurvy were reported but the prevalence of vitamin C deficiency among hospitalized subjects is sparsely assessed. Objectives: Evaluate the prevalence of vitamin C deficiency among hospitalized patients and search for clinical signs of scurvy and associated factors. Methods: Epidemiological, observational in routine care, prospective and monocentric study performed in the department of internal medicine at a hospital in Paris area between May and November 2014. Results: Out of 60 patients enrolled, 70% were deficient (serum ascorbic acid level (SAAL)<2 mg/L) and 13,3% were in hypovitaminosis (SAAL between 2 and 4,6 mg / L). 71,7% were under-nourished, 75% had one or more risk factors for deficiency. A weak correlation existed between SAAL and estimated daily intakes (EDI) of vitamin C (r=0,3 ; p = 0,035) and between vitamin C status and number of fruit and vegetables consumed per day (r=0,3; p=0,031). EDI for non-deficient exceeded EDI for deficient (p<0.05). Albuminemia and prealbuminemia levels were significantly lower, and CRP higher (p<0.05) in deficient and hypovitaminosis C. There was a high prevalence of clinical signs described in scurvy including asthenia, cutaneous xerosis, arthralgia, gingivitis, ecchymosis, hematomas and dry syndrome. We have identified 5 cases of scurvy. Conclusion: The prevalence of biological vitamin C deficiency is very high among hospitalized patients. The level of ascorbic acid should be interpreted with caution among patients with associated acute phase response. No link has been shown between clinical signs of scurvy and low serum ascorbic acid level.
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Master Thesis
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Sandra de Matos. Statut vitaminique C chez des sujets hospitalisés dans un service de médecine interne : analyse de fréquence, facteurs de risque et corrélation clinico-biologique. Médecine humaine et pathologie. 2016. ⟨dumas-01342570⟩

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