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Master Thesis

Iatrogenic Raynaud phenomenon: a systematic review and a network meta-analysis of peripheral vasoconstriction induced by beta-blockers

Abstract : Drug-induced Raynaud’s phenomenon (RP) has long been associated with the use of different classes, but its prevalence remains largely unknown. In order to synthesize available knowledge on this topic we conducted a systematic review, by using a mechanistic approach. We identified many drug classes and four main pathophysiological pathways. However, the level of evidence was poor in most cases and many questions remain. We then focalized on the example of beta-blockers and performed a network meta-analysis (NMA). This NMA aimed at assessing the prevalence of peripheral vasoconstrictions (PV) in patients taking beta-blockers and to explore the potential differences among beta-blockers. Our study reveals important heterogeneity among beta-blockers, with a protective effect of intrinsic sympathomimetic activity as compared with β1-aderenoceptors higher affinity. These results challenge recommendations on the use of beta-blockers inpatients presenting RP and PV.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01357049
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Submitted on : Monday, August 29, 2016 - 9:43:08 AM
Last modification on : Wednesday, July 15, 2020 - 8:56:03 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 12:17:15 PM

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  • HAL Id : dumas-01357049, version 1

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Charles Khouri. Iatrogenic Raynaud phenomenon: a systematic review and a network meta-analysis of peripheral vasoconstriction induced by beta-blockers. Pharmaceutical sciences. 2015. ⟨dumas-01357049⟩

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