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Master Thesis

Fonction plaquettaire au cours de l’activité physique chez le patient coronarien sous antiagrégants plaquettaires

Abstract : Promoting physical activity is one of the pillars of primary and secondary preventions following an Acute Coronary Syndrome (ACS). The number of patients admitted in Cardiac Rehabilitation after an ACS still remains insufficient. Some cardiologists fear that a coronary thrombosis due to a pro-aggregating environment could occur. Objective: Measure the variations of the P2Y12 receptor activity (PRU) of Cardiac Rehabilitation patients on Dual Antiplatelet Therapy (DAPT) during physical activity in accordance with their second platelet aggregation inhibitor treatment. Study the function of exercise training on the PRU at rest and during effort before and after exercise training programme. See the effect of different antiplatelet treatments on the PRU at rest and during physical activity. Material and Method: Observational and descriptive study of 15 adult patients admitted in Cardiac Rehabilitation who are on DAPT because of an angioplasty procedure. Two Verify Now P2Y12 tests were done on each patient before and after an effort during their first and last Cardiac Rehabilitation session. Results: 15 patients were admitted at the CHU Haut Lévèque between April 2015 and April 2016. During an acute physical exercise, there are no significant variations of the P2Y12 receptor activity (PRU) (p=0,32). There are no significant variations of the PRU (p=0,23) due to exercise training. The effect of the new treatments is not significantly more important than CLOPIDOGREL on the variation of the PRU (p = 0,68), during physical activity. Conclusion: Acute physical activity and exercise training has no effect on the biological activity of the P2Y12 receptor for the coronary patient on DAPT.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01389635
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, October 28, 2016 - 6:06:04 PM
Last modification on : Wednesday, August 23, 2017 - 4:33:54 PM

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Philippe Robino. Fonction plaquettaire au cours de l’activité physique chez le patient coronarien sous antiagrégants plaquettaires. Médecine humaine et pathologie. 2016. ⟨dumas-01389635⟩

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