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Master Thesis

Prurigo chronique de l’enfant : formes cliniques et profils de sensibilisation aux allergènes de l’environnement, étude prospective

Abstract : Background and objective: Prurigo in children can run a chronic course lasting several months to years, similar to adults, but it remains poorly studied. An allergic mechanism might be involved and we supposed that there were different clinical presentations depending on the allergen or environmental factors. The goal of the present study was to describe clinical features of childhood chronic prurigo and define different clinical forms and sensitization profiles to various environmental allergens. Methods: We conducted a prospective, multicenter study in 11 French Departments of Dermatology and Pediatric Dermatology between April 2015 and Mars 2016. A computerized questionnaire was used to collect data including demographics, clinical characteristics, quality of life scores (cDLQI), pruritus scores (P-VAS) and exposure to various environmental allergens. Skin prick tests and patch tests with reading at 20minutes, 48 and 96 hours, and eosinophils count, total IgE, serum specific IgE were performed. Results: 102 children were enrolled in the study (44 girls and 58 boys, mean age of 5.9 years). According the seasonality, patients were classified in three groups: perennial prurigo (37%), summer prurigo (44%) and non-summer prurigo (19%). Skin prick tests with delayed reading at 48 hours and patch tests were useful for investigating allergic prurigos. The mean cDLQI was 6.1/30 and mean P-VAS 3.7/10. Conclusion: Compared to adulthood, childhood chronic prurigo is usually a primitive dermatitis, due either to an allergic or non-allergic origin. We propose a simple classification according to seasonality into three groups, in order to reduce the prescription of unnecessary allergic tests and develop specific treatment (avoid exposure to causal agents, immunotherapy specific).
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01390745
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Submitted on : Wednesday, November 2, 2016 - 1:56:55 PM
Last modification on : Wednesday, August 23, 2017 - 4:41:06 PM
Long-term archiving on: : Friday, February 3, 2017 - 2:02:48 PM

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Claire Maridet. Prurigo chronique de l’enfant : formes cliniques et profils de sensibilisation aux allergènes de l’environnement, étude prospective . Médecine humaine et pathologie. 2016. ⟨dumas-01390745⟩

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