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Master Thesis

Utilité du site de localisation et de gestion des antidotes (SLOGAN) en toxicovigilance

Abstract : Context. The availability of studies on antidotes published agrees that there is a failure to store antidotes in all the countries. The localisation website and antidotes management (SLOGAN), allows to know in real time the status and location of stocks of antidotes. The aim of this study is to evaluate the usefulness of SLOGAN for the collection of toxicovigilance in the Aquitaine Poitou-Charentes (APC). Method. When an antidote is used in SLOGAN, the Poison Control Center (PCC) is notified by email. The antidotes used in SLOGAN were recorded from 1 January to 31 July 2016 to see whether the PCC had been contacted or not. We also observed the geographic distribution of calls to the PCC, and studied the consumption and availability of antidotes in the regional emergency structures. Results Nineteen cases were collected (12 undeclared CAP and 7 reported). The most commonly used antidotes are in decreasing order: FOMEPIZOLE®, CYANOKIT®, DIGIFAB®, PRAXBIND®, VIPERFAV®. Hospitals with the highest number of antidote outputs are in decreasing order: Bordeaux university Hospital, then Pau, Saintes and Angouleme hospitals. Conclusion. These results underline the usefulness of SLOGAN in the collection of toxicovigilance. There are several factors preventing the availability of antidotes: lack of regulation about the possession of antidotes, the rarity of some intoxication, the cost and strict limitation on the expiration dates Having recommendations (rotation / reimbursement of antidotes, provide training on how to use the antidotes) would optimize the availability of antidotes.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Monday, December 5, 2016 - 4:50:35 PM
Last modification on : Friday, November 15, 2019 - 3:41:21 PM
Long-term archiving on: : Thursday, March 23, 2017 - 12:41:37 AM


  • HAL Id : dumas-01409140, version 1



Caroline Mermet. Utilité du site de localisation et de gestion des antidotes (SLOGAN) en toxicovigilance . Médecine humaine et pathologie. 2016. ⟨dumas-01409140⟩



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