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Master Thesis

Traitement local de la gale chez le nourrisson et le jeune enfant : étude comparative de la tolérance du benzoate de benzyle et de la perméthrine

Abstract : Scabies is a common contagious disease caused by a mite, Sarcoptes scabiei hominis. Local treatments with 10% benzyl benzoate (BB10) or 5% permethrin (PER5) have proven their efficacy and are the most commonly used therapy in the world to treat both affected adults and children. However, the available tolerance data are limited to the effects observed during follow-up visits. This thesis is composed of two parts. A first part is an overview on scabies, focusing on pathophysiological and diagnostic aspects, and on the therapeutic options that are available. The second part is a study carried out to compare the immediate local tolerance of BB10 and PER5 in infants and young children, using a validated pain scale, the OPS scale (Objective Pain Scale). The study included 151 children aged one month to three years at the most, consecutively admitted for scabies and treated by BB10 or PER5 in the out-patient pediatric dermatology unit, at the University hospital Bordeaux, from January 2014 to September 2015. The average OPS score during care was 0.48 in the PER5 group and 4.77 in the BB10 group (p<0.001). Our study showed that the application of BB10 is associated with a significant increase in the pain score, which is much higher than that observed with PER5.
Document type :
Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01490749
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Wednesday, March 15, 2017 - 6:38:44 PM
Last modification on : Wednesday, August 23, 2017 - 4:41:34 PM
Long-term archiving on: : Friday, June 16, 2017 - 3:01:43 PM

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  • HAL Id : dumas-01490749, version 1

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Anne-Sophie Berthy. Traitement local de la gale chez le nourrisson et le jeune enfant : étude comparative de la tolérance du benzoate de benzyle et de la perméthrine. Sciences pharmaceutiques. 2017. ⟨dumas-01490749⟩

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