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Master Thesis

Comparison of induced gamma band responses to electrocortical stimulation and functional MRI during a language task: are they redundant or complementary to assess cognitive postoperative outcome in epilepsy surgery?

Abstract : The present study compared language mapping with language-induced Gamma Band Responses (GBRs) and Electro-Cortical Stimulation (ECS) and functional neuroimaging (fMRI), in patient with intracranial electrodes and evaluated the clinical relevance of GBRs to predict post-operative language outcome. Fourteen subjects with intractable epilepsy candidates for epilepsy surgery underwent intracranial EEG (iEEG) monitoring. During iEEG, conventional ECS and a language task (Lec1) involving two language processes (semantic and phonological) were performed. Thus we obtained iEEG signals, analysed in terms of GBRs (50–150 Hz) and behavioural features. In addition, a sub-group of 6 patients performed a language fMRI mapping. After surgery, the same language task (Lec1) was performed. Statistical analyses were computed: i) at every tested cortical site, language-induced GBRs were compared to language responses elicited by ECS, and fMRI results ii) post-operative outcomes of patients who underwent a resection upon cortical sites that exhibit language-induced GBRs were compared to post-operative outcomes of the other patients. Language-induced GBRs during predict ECS language interference and fMRI results with high specificity but low sensibility. Resections upon sites that showed language-related GBRs were not associated with more significant language post-operative decline. This study supports the feasibility of pre-surgical language mapping with language-induced GBRs. It supports the use of GBRs as a complementary tool of ECS and fMRI, as a screening method to perform preliminary functional maps to reduce ECS duration.
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Master Thesis
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Pauline Cuisenier. Comparison of induced gamma band responses to electrocortical stimulation and functional MRI during a language task: are they redundant or complementary to assess cognitive postoperative outcome in epilepsy surgery?. Human health and pathology. 2017. ⟨dumas-01674722⟩

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