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Master Thesis

La maladie de Verneuil ou hidradénite suppurée influence-t’elle le pronostic de la maladie de Crohn ?

Abstract : Introduction: hidradenitis Suppurativa (HS) is a chronic cutaneous, inflammatory disease with strong impact on quality of life. Crohn's disease (MC) belongs to inflammatory bowel diseases where perineal lesions as well as extra-digestive manifestations are frequently observed. The association between these two diseases is more and more described and it appears that HS could negatively influence the prognosis of CD. The aim of our study is to verify this hypothesis. Patients and Methods: this is a case-control with 1 on 4 ratio, retrospective and mono-centric study performed from 4645 MC of the MICISTA registry from the gastroenterology Unit of Saint-Antoine Hospital. HS cases were confirmed by review of the medical charts and dedicated clinical examination. Results: The prevalence of HS was 0.95% through 44 cases identified from 4645 MC. In the case-control comparison, HS-associated CD was more active (56% vs 40% years with active disease, p <0.001) and required more TNF antagonists (39% vs 23% years spent under anti-TNF, p <0.001) than CD alone. HS-associated CD was also associated with a higher risk of permanent stoma, 16.8% (IQR 7.5-33.3) versus 2.5% (IQR 0.8-7.4) in the control group (p <0.001 ). The univariate and multivariate analysis confirmed HS as an independent risk factor for permanent stoma with a Hazard Ratio of 6.29 [95% CI (2.30-38.33) p <0.001]. Conclusion: our study shows that HS has a negative effect on CD outcomes with a more active disease and an increased risk of permanent stoma, despite a higher use of anti-TNF agents.
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Master Thesis
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Louis-Marie Dumont. La maladie de Verneuil ou hidradénite suppurée influence-t’elle le pronostic de la maladie de Crohn ?. Médecine humaine et pathologie. 2017. ⟨dumas-01727078⟩

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