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Master Thesis

Émergence des méthodes non invasives pour évaluer l’arthrose en préclinique

Abstract : Osteoarthritis is one the most common and debilitating joint disease. This age-related degenerative disease is affecting millions of people worldwide, and has currently no effective treatment. The diagnosis in human pathology is based on pain and functional symptoms, and can be confirmed by radiography. Most current preclinical studies use the gold standard of histology to test new therapies, which cannot be used in the human clinical context. New non-invasive techniques allowing a longitudinal analysis of osteoarthritis in animal models have been set up: imaging techniques (radiography, MRI, micro-CT), gait analysis and biomarkers detection. The aim of this thesis is to describe the methods which can be used to assess osteoarthritis progression in preclinical studies, in order to test new therapies allowing transferable approaches in clinical studies. This manuscript will be illustrated with a preclinical study using radiography and gait analysis to test the effect of a new preventive treatment of osteoarthritis.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01758197
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Submitted on : Tuesday, June 5, 2018 - 11:48:10 AM
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Élodie Le Tilly. Émergence des méthodes non invasives pour évaluer l’arthrose en préclinique. Sciences du Vivant [q-bio]. 2016. ⟨dumas-01758197⟩

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