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Master Thesis

Efficacité de l'oligothérapie orale : revue systématique de la littérature

Abstract : INTRODUCTION: The objective of this study was to evaluate the efficacy of oral micro-nutrients, via clinical trials and meta-analyzes, to reach a general conclusion on the efficacy of oral oligotherapy. Our research has focused on the most commonly used elements in oral oligotherapy. METHOD: This work is a systematic review of the literature. Our primary endpoints were focused on the effectiveness of a one- or two-component protocol. RESULTS: 9 articles (12 studies, N = 1704) were included: 11 double blind randomized controlled trials and a meta-analysis. No studies have been included for bismuth, manganese and selenium. We had 7 different fields of application. DISCUSSION: All studies were in favor of oligotherapy. All RCTs included were of low level of evidence. Only the meta-analysis questioned the significance of the results and concluded that there was no superiority of chromium compared to placebo. For RCTs, the responsibility for a placebo effect on positive outcomes was likely. In view of the scarcity of studies and their low power, we could not determine the efficacy of copper, lithium, zinc, Cu-Au-Ag, Mn-Co, Mn-Cu and Zn -Ni-Co, needing to be invested scientifically. CONCLUSION: No reliable and robust evidence was found to guide final decisions about the efficacy of oral treatments in oligotherapy. The recommendation of this method using the trace elements must therefore be done in consciousness and knowledge of its limits.
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Nathalie Rolachon. Efficacité de l'oligothérapie orale : revue systématique de la littérature. Médecine humaine et pathologie. 2017. ⟨dumas-01785880⟩

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