Skip to Main content Skip to Navigation
Master Thesis

Electro-clinical correlation between seizures induced by direct electrical cortical stimulation and spontaneous seizures: relevance to define the epileptogenic zone

Abstract : This study, even based on a small sampling, is the first one evaluating the electro-clinical correlations between spontaneous and stimulation-induced seizures and determining the relevance of the stimulations-induced discharges to define the epileptogenic zone. Our results show a good overlap both for clinical and SEEG findings between the two types of seizures, therefore strongly suggesting that the epileptogenic network can be reactivated by the stimulation. This strengthens the usefulness of stimulation to delineate the epileptogenic zone. However, the removal of the brain area from which seizures were elicited did not seem to have any post-operative prognostic significance. This study was based on visual analysis of SEEG signais, and further studies aiming at comparing spontaneous and electrically-induced seizures could benefit from quantitative measurements of SEEG signais, such as the epileptogenicity index (Bartholomei et al., 2008) or the epileptogenicity maps (David et al., 2011).
Document type :
Master Thesis
Complete list of metadata

Cited literature [38 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01826169
Contributor : Jean-Hugues Morneau <>
Submitted on : Friday, June 29, 2018 - 9:59:44 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:23 AM
Long-term archiving on: : Thursday, September 27, 2018 - 9:52:27 AM

File

2017GREA5124_tardy_nastasia(1)...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-01826169, version 1

Citation

Nastasia Tardy. Electro-clinical correlation between seizures induced by direct electrical cortical stimulation and spontaneous seizures: relevance to define the epileptogenic zone. Human health and pathology. 2017. ⟨dumas-01826169⟩

Share

Metrics

Record views

125

Files downloads

346