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Master Thesis

SOX10, GATA3 et Récepteur à l’androgène : utilité dans le diagnostic différentiel entre cancer du sein triple négatif et adénocarcinome pulmonaire TTF1 négatif

Abstract : Triple-negative breast cancer (TNBC) has an increased risk of developing visceral metastases and other primary non-breast cancers, particularly lung cancer. The differential diagnosis of TNBC metastases and primitive cancers from other organs can be difficult due to lack of a TNBC standard immunoprofile. We analyzed the diagnostic value of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2), Thyroid transcription factor-1 (TTF1), Napsin A, Sry-related HMg-Box gene 10 (SOX10), GATA-binding protein 3 (GATA3) and androgen receptor (AR) in a series of 207 TNBC and 152 primary lung adenocarcinomas (LA). All tested TNBCs were TTF1 and Napsin A-negative. When comparing TNBC and TTF1-positive or negative LA, SOX10 had the best sensitivity (62.3%) and specificity (100%) as marker in favor of TNBC compared to LA, irrespective of TTF1 status (p<0.0001). GATA3 had moderate sensitivity (30.4%) and excellent specificity (98.7%) as marker for TNBCs compared to TTF1-negative LA and misclassified only 2/152 LA (1.3%). AR had a moderate sensitivity (30%) and good specificity (91.4%) and misclassified 20/152 (13.1%) LA. In SOX10-negative TNBC, GATA3 outperformed AR to differentiate TNBC from TTF1-negative LA [OR=23.4; 95%IC(5.2-105.6); p<0.0001] and [OR=4.9; 95%CI(2.15-11); p= 0.0001], respectively. Only 22/207 (10.6%) TNBC cases did not express any aforementioned marker. Based our results, the best sequential immunohistochemical analysis to differentiate TNBC from TTF1-negative LA is first SOX10 followed by GATA3, and finally AR. This order is important in the diagnostic workup of small biopsies from lung nodules in women with a previous history of TNBC.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01845319
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Élodie Laurent. SOX10, GATA3 et Récepteur à l’androgène : utilité dans le diagnostic différentiel entre cancer du sein triple négatif et adénocarcinome pulmonaire TTF1 négatif. Médecine humaine et pathologie. 2018. ⟨dumas-01845319⟩

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