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Master Thesis

Les colites ischémiques médicamenteuses en 2015 : étude rétrospective multicentrique

Abstract : Ischemic colitis is a common gut pathology and is responsible for one out of a thousand hospitalizations. Clinical manifestations include diarrhea, abdominal pain and rectal bleeding. Affected patients are over 60 years of age in 90% of the cases. Possible etiologies include low cardiac output, mesenteric blood flow obstruction and different drug exposures. Drugs that cause vasoconstriction (decongestants, NSAIDs, cocaine), increases in intraluminal pressure (neuroleptics, bisacodyl) or hypotension/low mesenteric blood flow (antihypertensive drugs) for example can cause ischemic colitis. A retrospective study was conducted in 2 hospitals located in Basse Normandie, France. Among 70 patients with a diagnosis of ischemic colitis in 2015, 8 were considered drug induced. The analysis of these 8 cases suggests that affected patients are young, have negligible medical history or chronic medication in comparison to the rest of our population. Drug induced ischemic colitis seems to progress favorably with noninvasive standard care which makes for a good overall prognosis. The potentially responsible drugs identified in the study were NSAIDs in 6 patients, bisacodyl for one and cocaine for the remaining one. Causal relationship remains difficult to establish considering the lack of documented detailed information for the analyzed cases. This study highlights the under reporting of drug associated adverse events since none of the cases were reported.
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Master Thesis
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Submitted on : Tuesday, October 2, 2018 - 2:43:21 PM
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Marion Mercerolle. Les colites ischémiques médicamenteuses en 2015 : étude rétrospective multicentrique. Sciences pharmaceutiques. 2017. ⟨dumas-01885980⟩



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