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Master Thesis

Les cauchemars dans l’état de stress post-traumatique. Impact des séances de blocage de la reconsolidation mnésique sous propranolol sur les cauchemars post-traumatiques

Abstract : Post-traumatic stress disorder affects nearly one in ten people in France. Nightmares are part of the intrusion symptoms in post-traumatic stress disorder. They are disabling, recurring, and difficult to treat. Unlike common nightmares, they can occur during any phase of sleep and they have a negative effect on sleep and quality of life. We chose to study the impact of an innovative treatment for post-traumatic stress disorder on attached nightmares. The Paris Mémoire Vive study (ParisMem) proposes a post-traumatic stress treatment consisting of 6 mnemonic reconsolidation blocking sessions. The treatment reactivates a traumatic memory while reducing its emotional involvement thanks to the action of propranolol. The objective of our study is to characterize the evolution of post-traumatic nightmares for patients treated in the ParisMem study, knowing that propranolol administered over a long period of time can sometimes lead to severe nightmares. We marked down the frequency of nightmare discomfort, evaluated throughout the protocol with the PCL-S self-questionnaire and studied the evolution of nightmares for these patients. Our results suggest that nightmares gradually diminish during this protocol, starting from the first session. This trend may be confirmed and further refined by a randomized placebo-controlled study. Blocking mnemonic reconsolidation with propranolol appears to be a promising technique for post-traumatic stress disorder, but also for post-traumatic nightmares.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01903535
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Claire Mallet. Les cauchemars dans l’état de stress post-traumatique. Impact des séances de blocage de la reconsolidation mnésique sous propranolol sur les cauchemars post-traumatiques. Médecine humaine et pathologie. 2018. ⟨dumas-01903535⟩

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