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Master Thesis

Impact du relais des anticoagulants sur la transfusion péri-opératoire chez les patients en fibrillation atriale

Abstract : Objective: in case of a planned surgery, a patient suffering from atrial fibrillation (AF) and having long-term oral anticoagulant treatment, should receive or not an anticoagulation bridging depending on his condition according to French recommendations. The aim of this study is to assess the impact of the bridging taken alone or in combination with other risk factors on the transfusion. Material and methods: the study is retrospective and monocentric. The dataset was made of individuals older than 18, with nonvalvular AF, treated with oral anticoagulants and having a surgery planned between January the 1st 2014 and December the 31st 2016. The data was interpreted through Odds-Ratio standards [CI 95%]. Results: anticoagulation bridging was not detected as a risk factor for transfusion. However, the combination of bridging with the following individual risk factors increased the probability of transfusion: chronical renal failure OR 3,5 (IC95 [1,4-8,7]; p<0,05) and preoperative anemia OR 3,7 (IC95 [1,4-9,8]; p<0,05). In addition, blood transfusion increased the length of stay +5,7 j (IC95 [3,9-7,5]; p<0,0001). Recommendations were not applied in 48% of cases. Conclusion: the combination of a bridging with another risk factor increases the probability of transfusion. A better application of recommendations should reduce the risk of transfusion and limit the socio-economic impact of blood consumption.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01913713
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Submitted on : Tuesday, November 6, 2018 - 2:59:28 PM
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Juliette Donnou-Souleau. Impact du relais des anticoagulants sur la transfusion péri-opératoire chez les patients en fibrillation atriale. Médecine humaine et pathologie. 2018. ⟨dumas-01913713⟩

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