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Master Thesis

Facteurs de risque de macrosomie fœtale : une étude cas témoins menée chez les patientes présentant un diabète gestationnel suivies au CHU de Bordeaux

Abstract : Objectives: gestational diabetes mellitus (GDM) diagnosis is a factor associated with increased risk of maternal and fetal complications including fetal macrosomia (FM). With the rising prevalence of GDM in France, it is likely that incidence of FM increases in the future. The aim of our study was to identify the risk factors of FM in patients with GDM. Methods: this was an observational, retrospective, monocentric, control-case study conducted by the hospital of Bordeaux using data from 2003 to 2018. The population of the study was composed of 168 singleton pregnancies diagnosed with GDM. 84 women of them, who gave birth to a macrosomic offspring (birth weight ≥ 4 kg) were compared to a 84 women without macrosomia. Results: the following outcomes were significantly positively associated with fetal macrosomia: medical history of fetal macrosomia (p<0.001); body mass index before conception (p=0.038); women weight at the first (p=0.006) and last consultation (p=0.021); fasting blood glucose during the third trimester (p=0.001); the difference of fasting blood glucose between the second and last trimester (p=0.04) ; the last HbA1C during pregnancy (p=0.018); the term (p<0.0001) ; delivery by caesarean section (p=0.021). Conclusion: the main conclusion of this study is the evidence of a link between the weight of women prior to conception or throughout their pregnancy and FM. These results show the importance of public health measures aimed at preventing overweight and obesity, as well as weight gain throughout the pregnancy and thereby maternal and fetal complications during pregnancy including FM.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01954686
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Submitted on : Thursday, December 13, 2018 - 7:01:41 PM
Last modification on : Saturday, December 15, 2018 - 1:18:08 AM
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Élise Menant. Facteurs de risque de macrosomie fœtale : une étude cas témoins menée chez les patientes présentant un diabète gestationnel suivies au CHU de Bordeaux. Médecine humaine et pathologie. 2018. ⟨dumas-01954686⟩

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