Skip to Main content Skip to Navigation
Master Thesis

Évaluation d'une séquence IRM 4D flow dans l'exploration du flux portal

Abstract : Objective : To evaluate a flow-sensitive 4D MR imaging flow sequence in comparison with a 2D MR flow sequence used as reference. Material and methods : This prospective study was approved by the local ethics committee and written informed consent was obtained from all participants. A prototype 4D flow MR imaging sequence, with an acquisition duration compatible with the clinical practice, was assessed at 1.5T. The portal venous hemodynamics was analyzed, with and without baseline correction, in 26 patients. Quantitative analysis were performed measuring flows and peak velocities using a commercial solution and an in-house software. Inter-observer analysis, mass conservation study and qualitative analysis were also performed. Portal flows and velocities were compared to the standard 2D flow sequence. Results : Twenty six patients were included, 7 considered healthy and 7 cirrhotic (5 with portal hypertension). The average acquisition time was 6min14±1min51. The mean portal vein flow rate measured on the 4D flow sequence was 0.99±0.44 L/min without correction and 1.07±0.40 L/min with correction, significantly correlated with the flow rate measured with 2D PC MR imaging (1,06±0.48 L/min) (r=0.82 and r=0.76 respectively without and with correction (p<0.001)). No significant correlation between 4D et 2D peak velocities was observed. Conclusion : In a limited acquisition time compatible with the clinical practice , the 4D flow MR sequence was able to properly quantify portal flow and to visualize the hepatic hemodynamics.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [45 references]  Display  Hide  Download
Contributor : Philippe Barbey <>
Submitted on : Monday, March 11, 2019 - 2:45:40 PM
Last modification on : Sunday, May 5, 2019 - 1:20:57 AM
Long-term archiving on: : Wednesday, June 12, 2019 - 3:00:41 PM


Raphaël Pichois. Thèse d'exe...
Files produced by the author(s)


  • HAL Id : dumas-02063791, version 1



Raphaël Pichois. Évaluation d'une séquence IRM 4D flow dans l'exploration du flux portal. Médecine humaine et pathologie. 2018. ⟨dumas-02063791⟩



Record views


Files downloads