Facteurs prédictifs d'ostéoporose chez des patients atteints d'hypertparathyroïdie primaire dans une population afro-caribéenne

Abstract : Introduction: Because uncertain, we explore predicting factors to osteoporosis secondary to PHPT in an afro-caribbean population Methods: We conducted a retrospective study in the Pointe-à-Pitre’s University Hospital, France, and gathered the characteristics of adult PHPT patients who came for a Dual energy x-ray (DXA) densitometry. VD was measured by electrochemiluminescence; a level of VD > 30ng/mL was labeled as sufficient, inadequate between 20 and 30, insufficient between 10 and 20 and deficient if < 10. Results: 68 patients were included (80.9% of women, of which 92.7% were menopaused); average age: 66.1±11.3 years old, average body mass index: 27.95±4.97 kg/m2 ; diabetes : 53.7%. VD status was thus distributed: sufficient: 50%, inadequate: 29.4%, insufficient: 16.2% and deficient: 4.4%. T-scores were respectively of -1.26 ± 0.77 and -2.40±1.62at the femoral neck and lumbar spine. Regression analysis of the collected data enabled us to highlight the existence of independent factors for decreased BDM: VD levels and lumbar osteopenia (OR 0.853 [0.732-0.995], p=0.043); weight and lumbar osteoporosis (OR 0.793 [0.641-0.982], p=0.033); age and osteopenia (OR 0.830 [0.830-0.987], p=0.035); feminine sex and femoral neck osteopenia (OR 63.968 [0.1.106-3968.3], p=0.045); ALP and osteoporosis (OR 1.133 [1.010-1.270], p=0.033); age and osteopenia (OR 0.830[0.698-0.987], p=0.035). Conclusion: Apart from the generally known risk factors, a diminished level of VD is a determining factor for osteoporosis in PHPT patients in an afro-caribbean population.
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François Delanoë. Facteurs prédictifs d'ostéoporose chez des patients atteints d'hypertparathyroïdie primaire dans une population afro-caribéenne. Endocrinologie et métabolisme. 2017. ⟨dumas-02067931⟩

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