Évaluation d’une supplémentation chronique en nitrate et citrulline sur la performance à l’effort et la fonction cardiovasculaire du sujet âgé

Abstract : Increased nitric oxide (NO) bioavailability may improve exercise performance and vascular function. It remains unclear whether older adults (60-70 years) who experience a decreased NO bioavailability may benefit from chronic NO precursor supplementation. This randomized double-blind trial aims to assess the effect of chronic NO precursor intake on vascular function and exercise performance in older adults (60-70 years old). Twenty-four healthy older adults (12 females) performed vascular function assessment and both local (knee extensions) and whole-body (incremental cycling) exercise tests to exhaustion before and after one month of daily intake of a placebo (PLA) or a nitrate-rich salad and citrulline (N+C, 520mg nitrate and 6g citrulline) drink. Arterial blood pressure (BP) and stiffness, post-ischemic, hypercapnic and hypoxic vascular responses were evaluated. Prefrontal cortex and quadriceps oxygenation was monitored by near-infrared spectroscopy. N+C supplementation reduced mean BP (- 3.3mmHg; p=0.047) without altering other parameters of vascular function and oxygenation kinetics. N+C supplementation reduced heart rate and oxygen consumption during submaximal cycling and increased maximal power output by 5.2% (p<0.05), but had no effect on knee extension exercise performance. These results suggest that chronic NO precursor supplementation in healthy older individuals can reduce resting BP and increase cycling performance by improving cardiorespiratory responses.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [92 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02088797
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, April 3, 2019 - 10:52:52 AM
Last modification on : Friday, April 5, 2019 - 1:18:39 AM

File

2019GREA5004_pelen_felix(1)(D)...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02088797, version 1

Citation

Félix Pelen. Évaluation d’une supplémentation chronique en nitrate et citrulline sur la performance à l’effort et la fonction cardiovasculaire du sujet âgé. Médecine humaine et pathologie. 2019. ⟨dumas-02088797⟩

Share

Metrics

Record views

44

Files downloads

49