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Master Thesis

Prévention des Infections Fongiques Invasives (IFIs) par le posaconazole comprimé chez le patient d’hématologie : intérêt du suivi thérapeutique pharmacologique dans la prise en charge du patient

Abstract : In hematology, neutropenic patients are at high risk of developing invasive fungal infection. Mortality is important in myeloid hematological malignancies, so that antifungal prophylaxis is especially indicated. Posaconazole (PZC) oral tablet, which is a triazole antifungal agent, has improved bioavailability compared to oral suspension for which the dosage was optimized with Therapeutic Drug Monitoring (TDM) by measuring blood concentration. The role of TDM when using oral PCZ tablet has been studied : according to literature and prospective monitoring of patients in Rennes hospital, TDM appears to be helpful, because of an inter and intra-individual high pharmacokinetic variability, and because some patients may maintain low PZC levels while others are highly exposed. TDM allows adjusting the dosage of PCZ tablet with underexposed or highly-exposed patients and may ensure an individualized antifungal treatment.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02147090
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Submitted on : Tuesday, June 4, 2019 - 2:16:00 PM
Last modification on : Thursday, July 9, 2020 - 12:30:44 PM

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Chloé Bignon. Prévention des Infections Fongiques Invasives (IFIs) par le posaconazole comprimé chez le patient d’hématologie : intérêt du suivi thérapeutique pharmacologique dans la prise en charge du patient. Sciences du Vivant [q-bio]. 2018. ⟨dumas-02147090⟩

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