Pertinence du Questionnaire de Plainte Cognitive (QPC) comme outil d'orientation dans la stratégie de dépistage des troubles cognitifs dans la population spécifique VIH+

Abstract : Background: HIV-associated neurocognitive disorders have an estimated prevalence of 20 to 50%. In France, expert reports first recommend investigating cognitive complaints using a questionnaire such as the Questionnaire de Plainte Cognitive (QPC). However, its specific use in the HIV population has never been studied. We aim to determine the degree of agreement between QPC and the presence of HIV-associated neurocognitive disorders according to Frascati criteria, established by a battery of neuropsychological tests. Methods: Data from patients who performed both a QPC and a battery of neuropsychological tests over a six-month follow-up period were evaluated retrospectively. Results: A total of 121 patients were selected, with a median age of 53.1 years, predominantly males. Median duration of HIV infection follow-up was 21.6 years. Among participants, 92.6% had an undetectable plasma viral load, 49.6% had a nadir CD4 less than 200/mm3 and 23.1% had a CDC stage C. Median CD4 cell count was 686/mm3. Prevalence of HIV-associated neurocognitive disorders was 57%, including 28.9% of Asymptomatic Neurocognitive Impairment, 24.8% of Mild Neurocognitive Disorder and 3.3% of HIV-associated Dementia. The analyze shows no agreement between QPC and HIV-associated neurocognitive disorders (kappa = - 0.007). The second item of the QPC (Impression of worse memory in comparison to peers) was the only one that has contributed to the identification of HIV-associated neurocognitive disorders (kappa= 0.244). Conclusions: This study demonstrates that QPC is not relevant in the screening strategy for HIV-associated neurocognitive disorders. Specific questionnaire to assess cognitive complaints among people living with HIV is needed.
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Submitted on : Monday, July 1, 2019 - 3:19:58 PM
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Maelys Tixier. Pertinence du Questionnaire de Plainte Cognitive (QPC) comme outil d'orientation dans la stratégie de dépistage des troubles cognitifs dans la population spécifique VIH+. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02169835⟩

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