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Master Thesis

Mise en place d'une activité de transplantation de microbiote fécal dans un centre hospitalier universitaire et suivi des patients traités

Abstract : The gut microbiota represent all the microorganisms that inhabit the intestinal tract, and it is connected with human cells and the food we eat. Many functions are attributed to it and its imbalance, named dysbiosis, is observed in various diseased conditions, such as particular infectious, digestive and metabolic diseases. The principle of Fecal Microbiota Transplantation (FMT) consists in directly change the recipient’s gut microbial by the administration of a solution of fecal matter from a voluntary donor. Currently, FMT is only recommended for recurrent Clostridium difficile infection, but many studies show its interest on other diseases. This report aim at describe the implementation of FMT at the Caen University Hospital Center (UHC) and cohort of treated patients. Among the improvement actions identified by le Groupe Français de Transplantation Fécale (GFTF), the choice to deep-freeze the transplant has eased the logistical constraints of its circuit. The drafting of suitable consents for the donor and recipient of FMT have also been developed. This work was also the subject of a survey conducted among the UHCs performing FMT. It reveals a certain heterogeneity of practices: place of emission of the donation, place of preparation, the processing method. This could lead to differences in the quality and safety of the transplant. Given the heterogeneity observed during the survey, The COSMIC project, led by GFTF under the aegis of the National Academy of Pharmacy, aims to harmonize and secure FMT.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02176782
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Submitted on : Monday, July 8, 2019 - 2:23:30 PM
Last modification on : Tuesday, April 14, 2020 - 12:09:14 PM

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Batiste Martel. Mise en place d'une activité de transplantation de microbiote fécal dans un centre hospitalier universitaire et suivi des patients traités. Sciences pharmaceutiques. 2018. ⟨dumas-02176782⟩

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