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Master Thesis

Efficacité de la stimulation électro-convulsive en cure de consolidation dans un modèle animal de dépression, la souris MAP6-KO : le rôle essentiel de la survie neuronale

Abstract : Electroconvulsive therapy (ECT) is an efficient and rapid treatment commonly used in psychiatry to treat severe or resistant depressive episodes, decompensation of bipolar disorder or resistant schizophrenia. Despite significant clinical use since the late 1930s, the neurobiological mechanisms underlying curative action remains poorly understood nowadays. The aim of this study is to analyze the action on adult neurogenesis of electro-convulsive stimulation (ECS), the animal equivalent of ECT, in an animal model of depression. Using MAP6-KO mice, a genetic model that constitutively exhibits features relevant to some aspects of depression, we analyzed the behavioral and biological consequences of treatment with ECS in consolidation treatment (2 stimulations per week for 5 weeks), after an initial course of treatment (10 stimulations over a 2-week period). ECS treatment in a consolidation protocol had a beneficial effect on constitutive behavioral defects. We showed that behavioral improvement is associated with a strong increase in the survival of neurons created during the initial course. These results thus show that the mechanism of action of the ECS in consolidation cure is related to the improvement of the neuronal survival.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02303206
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Submitted on : Thursday, October 3, 2019 - 5:24:08 PM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM

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Albane Pelluet. Efficacité de la stimulation électro-convulsive en cure de consolidation dans un modèle animal de dépression, la souris MAP6-KO : le rôle essentiel de la survie neuronale. Médecine humaine et pathologie. 2019. ⟨dumas-02303206⟩

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