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Master Thesis

Infections à Clostridium difficile chez les patients âgés de 18 à 65 ans

Abstract : Background: Clostridium difficile infection (CDI) is the first cause of post-antibiotic diarrhea and the most common pathogen of healthcare- associated infection in United-states. This infection usually occurs in elderly, but seems now to increase for the young population. The aim of this study is to describe epidemiological and clinical characteristics of this young population under than 65 years old with CDI, and especially patients under 35 years old. Methods: We conducted a retrospective analysis from May 2016 to March 2018. Epidemiological, biological and clinical information were analyzed for each episode of CDI in patient from 18 to 65 years old. Then, we compared CDI in patients under the age of 35 years old with patients over 35 years old. Result: We analyzed 239 episodes of CDI in 207 patients. Average age was 49,4 years old. 25,5% of cases were Community-associated. Prior exposure to antibiotic occurred for 77% of case. 4,2% stools samples were positive for RTO78 and 1,7% for RT O27. Patients under 35 years old had more Inflammatory Bowel Disease (IBD) (p 0,001). Contact with infants or with elderly was more frequent in this population (p 0,049). Conclusion: Among patients with CDI from 18 to 65 years old, presence of IBD and contact with infant under 3 years or elderly over 75 are more frequent in patients under 35 years old than over 35 years old. Case-control study is needed to strength these results.
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Submitted on : Wednesday, November 13, 2019 - 3:33:24 PM
Last modification on : Friday, October 23, 2020 - 4:58:57 PM


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Anaïs Thouret. Infections à Clostridium difficile chez les patients âgés de 18 à 65 ans. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02361796⟩



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