Skip to Main content Skip to Navigation
Master Thesis

Rehabilitation in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: results from the Grenoble experience

Abstract : Introduction : For decades, patients with pulmonary hypertension (PH) were advised to avoid exercise in fear of deterioration in right heart function. Since then, recent studies have reported that rehabilitation programme in expert centres may have a specific role in the management of pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Methods : All consecutive patients with PAH or CTEPH admitted in a French rehabilitation centre between March 2010 and May 2019 were evaluated retrospectively on functional, biological parameters, and haemodynamics. We also apply a recently validated abbreviated versions of the ESC/ERS pulmonary hypertension risk stratification. Results : 41 patients were included (mean age 59,6 +/- 18,1 years-old). The rehabilitation programme improved the risk assessment grade (-0,25 point, 95% CI, -0,45 to -0,07), the NYHA functional class and haemodynamic parameters including mPAP (- 6,3 mmHg, 95% CI, -12,3 to -0,3) and right atrial pressure. The 6-minute walk distance improvement exceeded by far the minimal important difference of 33 m, but was not statistically significative (53,1 m, 95% CI, -17,7 to 123,9). 21,9% of participants suffered adverse events, the majority of which was not linked with physical activity, and no major adverse events (progression of right heart failure or death) were reported. Conclusion : Among patients with PAH or CTEPH, the rehabilitation programme, in a supervised setting, as add-on to medical therapy is relatively safe and effective to improve functional capacity, hemodynamic parameters, and risk assessment grade.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [137 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02383470
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, November 27, 2019 - 5:25:13 PM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM

File

2019GREA5125_barret_thomas(1)(...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02383470, version 1

Citation

Thomas Barret. Rehabilitation in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: results from the Grenoble experience. Human health and pathology. 2019. ⟨dumas-02383470⟩

Share

Metrics

Record views

64

Files downloads

72