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Master Thesis

Les caractéristiques associées au traumatisme précoce chez les patients souffrant de trouble bipolaire

Abstract : Bipolar disorder is a recurrent affective disorder that alterns maniac and depressive episodes. The bipolar disorder I concerns 0,6% of the world community population whereas the bipolar disorder II concerns 0,4%. The prevalence of the whole bipolar disorder spectrum has been estimated to 2,4%. Its heritability has been estimated up to 85%. The part attributable to other risk factors has been estimated up to 38%. Among them the childhood trauma is the most important. Childhood trauma has been defined by the WHO as a cluster of physical, emotional, sexual abuse and neglect. It has been reported by about 50% of bipolar disorder patients. It is associated with a greater risk of bipolar disorder with an odd-ratio of 2,6. It is also associated with a more severe presentation of the disorder with a lower age at onset up to 7 years (OR=1,8), a greater risk of suicid, suicid attempts and ideation (OR=2,3), more rapid cycling (OR=1,9), more psychosis during episodes (OR=1,5), more anxiety (OR=1,9), medical, substances use disorders and borderline personnality comorbidities. This review highlights the role of that onset and severity risk factor and suggests that it should be investigated in clinical practice in order to offer convenient therapeutics to patients reporting history of abuse and/or neglect. This review suggests, through the abundant litterature about childhood trauma, that more studies on pharmacological and psychotherapeutic treatments specific to that group of patients should be conducted.
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Submitted on : Wednesday, December 18, 2019 - 3:13:30 PM
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  • HAL Id : dumas-02418054, version 1




Umuhoza Palatin Ndekezi. Les caractéristiques associées au traumatisme précoce chez les patients souffrant de trouble bipolaire. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02418054⟩



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