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Master Thesis

Densité minérale osseuse quatre ans après chirurgie bariatrique : une étude longitudinale monocentrique

Abstract : Introduction: bone Mineral Density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare. Design and methods: an observational longitudinal study in obese patients undergoing SG or RYGB was performed. Whole body areal BMD and BMD at the hip, femoral neck and spine were measured by dual-energy x-ray absorptiometry (DXA) before and yearly after SG or RYGB during 4 years. Calciotropic hormones were also measured. Results: forty-seven patients undergoing RYGB surgery and 28 patients undergoing SG were included. Four years after RYGB, lumbar spine BMD declined by 2.8 % ± 5.8, femoral neck BMD by 8.6 % ± 5, total hip BMD by 10.9 % ± 6.3 and whole-body BMD by 4.2 % ± 6.2 (p < 0.05). Four years after SG, femoral neck BMD declined by 8.1% ± 5.5 and total hip BMD by 7.7 % ± 6.4 (p < 0.05). Whole-body BMD did not significantly differ throughout the follow-up. Despite an increase of vitamin D with supplementation in the two groups, PTH levels increased slightly in the RYGB group and decreased modestly in the SG group (p < 0.05 in both groups). Conclusions: bone loss after RYGB and SG continues after the first year, but bone loss slows down after the first 2 years. Bone loss after 4 years is comparable between the two procedures, except in the hip.
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https://dumas.ccsd.cnrs.fr/dumas-02418862
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Olivier Cadart. Densité minérale osseuse quatre ans après chirurgie bariatrique : une étude longitudinale monocentrique. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02418862⟩

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