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Master Thesis

Viscosité sanguine et fonction cardio-vasculaire chez des résidents de haute altitude

Abstract : While 5-33% of highlanders permanently living at high altitude (> 2,500 m) worldwide develop chronic mountain sickness (CMS), the underlying mechanisms of excessive erythrocytosis (EE) and CMS symptoms remain incompletely understood. The objective of this study was to characterize blood viscosity and cardiovascular function in highlanders with and without CMS. Forty-one Andean highlanders permanently living at 5,100 m, including 15 highlanders without EE (hemoglobin concentration [Hb] < 21 g·dL-1), 13 highlanders with EE ([Hb] ≥ 21 g·dL-1) without CMS symptoms (Qingshai CMS score ≤ 5; CMS-) and 13 highlanders with EE and CMS symptoms (Qingshai CMS score 6-14; CMS+) were compared to 13 Andean healthy highlanders living at 3,800 m and 10 Caucasian healthy lowlanders living at sea level. Whole blood viscosity, standard echocardiographic parameters and post-ischemia reperfusion assessed by near-infrared spectroscopy were investigated. At 5,100 m, [Hb] difference between highlanders with and without EE was not associated with differences in blood viscosity, while highlanders without EE at 5,100 m had higher blood viscosity than highlanders at 3,800 m with similar [Hb]. Regarding the vascular function, CMS+ had larger post-ischemic vasodilatation, compared to lowlanders and highlanders at 3,800 m. Compared to sea level, the right atrium was enlarged in highlanders at 3,800 m and in all highlanders at 5,100m but the cardiac function was preserved. These results highlight hemorheological and cardiovascular responses to chronic hypoxic exposure that may allow tolerance to permanent high-altitude residence and underlie the development of CMS.
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Master Thesis
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Submitted on : Friday, December 20, 2019 - 9:58:37 AM
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Emmanuelle Loyrion. Viscosité sanguine et fonction cardio-vasculaire chez des résidents de haute altitude. Human health and pathology. 2018. ⟨dumas-02420663⟩

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