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Master Thesis

Quantitative measurement of lung vasculature on CT in pulmonary fibrosis: correlation with clinical parameters and prognosis

Abstract : Objectives : To investigate the relationship between CT measurement of pulmonary vessels volume, number and area and clinical parameters and prognosis in pulmonary fibrosis. Material and methods : The following CT vascular parameters were retrospectively extracted from the unenhanced chest CTs of 24 consecutive patients presenting with a CTpattern of probable or certain UIP: pulmonary vessel volume (PVV), number of vessels (NoV), number of vessels <5 mm². We studied the correlations of those quantitative CT variables with the following functional follow-up parameters: yearly decrease of raw and percentage of decline of FVC, DLCO and KCO. Additionally, we checked the correlations of those parameters with patients’ demographics, relevant medical history, clinical events, the 6 minute walk test and needing of oxygen therapy. Results : 24 patients with UIP scan pattern were included. The median age was 76 years old (Interquartile ratio =12) with a M/F ratio of 3. There were significant correlations between PVV (R= -0.51, p= 0.01), NoV (R= 0.5, p= 0.02), NoV 5 (R= 0.46, p= 0.03) and the yearly decline of DLCO and between PVV and the decline of KCO (R= -0.56, p= 0.009). Furthermore, there was a significant association between PVV and 6 MWT desaturation (R= -0.52, p= 0.03) and between PVV and 6 MWT for the distance walked in percentage predict (R= -0.59, p= 0.009). Conclusions : Quantitative CT lung vascular parameters are significantly correlated to DLCO and KCO decline and therefore patients’ prognosis in UIP pattern ILDs.
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Master Thesis
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Loïc Falque. Quantitative measurement of lung vasculature on CT in pulmonary fibrosis: correlation with clinical parameters and prognosis. Human health and pathology. 2018. ⟨dumas-02421795⟩

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