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Master Thesis

Évolution de l’épaisseur choroïdienne sous fovéolaire en population générale âgée en fonction des facteurs oculaires et cardiovasculaires : l’étude ALIENOR

Abstract : Purpose: to assess normative data of Sub-foveal choroidal thickness (SFCT) evolution in French elderly subjects and to determine the factors influencing its rate of change, such as ocular and cardiovascular factors. Design: population-based longitudinal study: the ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) Study since 2009. Regarding this paper, collected data ranged from February 2011 to May 2017 during three different exams. Mean follow up duration was 3.6 years (SD: 0.98). Subjects and Methods: a detailed ophthalmic examination including EDI-OCT (enhanced depth Imaging-Optical coherence tomography) were obtained in 282 subjects who were aged 77 years or older. Participants were included if they attended at least 2 of the 3 exams in order to estimate a rate of evolution. Mixed linear models with random effect were used to evaluate the associations of SFCT with age, sex, ocular parameters and vascular risk factors, and its evolution over time. Results: mean age of the subjects was 82.3 years. Mean SFCT at baseline was 208.5 µm ranging from 17 to 457 µm. SFCT decreased by 10.8 µm per year. Each variable and model were adjusted for age, time, time2, sex, sex*time, and Axial length (AL). At baseline, SFCT was significantly thinner in older subjects, in women, with axial length (AL) > 26 mm, with Intra-Ocular Pressure (IOP) superior to the median, and in left eye. Evolution over time showed significantly decreased thinning for women, and for participants with diabetes, but there was not significantly associated with others factors. In the final stepwise backward linear mixed model, only diabetes was significantly associated with evolution over time of SFCT. Conclusion: mean SFCT decreased over time and tend to reach a plateau. SFCT was significantly negatively associated with age, in women, with high AL, high IOP, left side at baseline. Rate of evolution of choroidal thickness was associated with women positively, and diabetes positively.
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Gobain Chan. Évolution de l’épaisseur choroïdienne sous fovéolaire en population générale âgée en fonction des facteurs oculaires et cardiovasculaires : l’étude ALIENOR. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02427090⟩

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