Skip to Main content Skip to Navigation
Master Thesis

Association entre exposition atmosphérique aux polychlorobiphényles (PCB) et cancer du sein : une étude cas-témoins nichée dans la cohorte E3N

Abstract : Background: Although the genetic and hormonal factors of breast cancer are well identified, they do not explain all cases. Epidemiological and experimental studies have suggested that exposure to environmental pollutants, particularly those with potential estrogenic properties, may have a role in the development of breast cancer. Objective: This study aims to estimate the association between cumulative atmospheric exposure to polychlorinated biphenyls (PCBs) and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011 in metropolitan France. Method: The E3N cohort, started in 1990, included nearly 100,000 French women born between 1925 and 1950 and members of the MGEN. A nested case-control study of 5,349 cases and 5,349 matched controls was conducted within the French E3N cohort. The addresses of the participants were geocoded. Atmospheric PCB concentrations were estimated by a CHIMERE model and were assigned to subjects based on their residential history. A cumulative PCB exposure was calculated for each subject from inclusion to index date (case diagnosis date). Breast cancer odds ratios (ORs) associated with cumulative PCB exposure and their 95% confidence intervals (CI95%) were estimated using multivariate conditional logistic regression models. Results: Overall, our results showed a statistically significant increase in breast cancer risk related to cumulative atmospheric exposure to PCBs as a continuous variable, after adjustment (OR = 1.13; 95% CI: 1.02-1.24). After stratification by menopausal status at index date, a statistically significant association was observed only in postmenopausal women (OR = 1.13; 95% CI: 1.03-1.25). No statistically significant associations were observed when studying PCBs exposure in quintiles. Discussion: This study is the first to have estimated the impact of atmospheric exposure to PCBs on breast cancer risk. Our results showed a statistically significant increase in breast cancer risk. However, these results should be interpreted with caution and further studies are needed to confirm them.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [139 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02435241
Contributor : Isped Ub <>
Submitted on : Friday, January 10, 2020 - 4:30:38 PM
Last modification on : Monday, May 4, 2020 - 11:26:26 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-05-04

Please log in to resquest access to the document

Identifiers

  • HAL Id : dumas-02435241, version 1

Collections

Citation

Floriane Deygas. Association entre exposition atmosphérique aux polychlorobiphényles (PCB) et cancer du sein : une étude cas-témoins nichée dans la cohorte E3N. Santé publique et épidémiologie. 2019. ⟨dumas-02435241⟩

Share

Metrics

Record views

158