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Master Thesis

Uvéites non-infectieuses : facteurs prédictifs de rechute des patients sous Méthotrexate ou Mycophénolate Mofétil

Abstract : Purpose: methotrexate and mycophenolate mofetil are corticosteroid-sparing agents prescribed to patients with non-infectious, non-anterior uveitis. Recently, anti-TNFα treatment was approved. The aim of this study was to identify predictors of methotrexate or mycophenolate mofetil (MTX/MMF) treatment failure within the year of treatment. Methods: this retrospective monocentric study included patients with non-anterior, non- infectious uveitis treated with MTX/MMF between 2010 and 2018. Demographic, therapeutic, immunological, and ophthalmological data were collected at baseline. Results: among 95 treated eyes, 60 (63%) responded to treatment and 35 (37%) did not. In multivariate analyses, the independent risk factors of failure one year after starting treatment were posterior uveitis (OR=6.49; 95% CI, 1.90-22.20) and macular thickness over 350 μm (OR=4.57; 95% CI, 1.53-13.65). Conclusions: patients with posterior uveitis and macular thickness over 350 μm were more prone to treatment failure with MTX/MMF. This should lead to discuss the prescription of anti-TNFα when non-steroid systemic immunomodulatory treatment is required. Keywords: Non-infectious uveitis, immunosuppressive agent, predictive factor, treatment failure.
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https://dumas.ccsd.cnrs.fr/dumas-02442976
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Hélène Noël. Uvéites non-infectieuses : facteurs prédictifs de rechute des patients sous Méthotrexate ou Mycophénolate Mofétil. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02442976⟩

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