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Master Thesis

Arenicola marina : le nouvel espoir marin pour la santé publique

Abstract : Since millennia, blood is known indispensable to life. It is thanks to this one, that oxygen mainly, and the nutrients are transported to tissues and organs. In recent years, research has turned to the development of a blood substitute, able to replace our red blood cells during transfusions or as a graft preservation solution. As life expectancy increases, chronic diseases are therefore more and more frequent with an increase in renal or cardiac insufficiency. Unfortunately, more than 50% of the grafts cannot be transplanted because of poor storage due to hypoxia and a time lapse between taking and transplanting too much. Add to this the problems, blood compatibility, the risk of transmission of infectious diseases or the lack of blood donation. Tests conducted with synthetic haemoglobin-based oxygen transporters all revealed adverse risk benefit with significant adverse effects. A marine worm, Arenicola marina, discovery by Doctor Franck Zal, seems to have the bearing capacity for all these problems. Its extracellular haemoglobin capable of transporting 156 molecules of oxygen is 50 times more “oxygenating” than ours and can be used in many areas including the conservation of grafts, oxygenating dressings, trauma brain injury, polytrauma, or as a "booster" of cell cultures, as shown by many studies that we have presented.
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Master Thesis
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Submitted on : Wednesday, January 22, 2020 - 11:53:12 AM
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  • HAL Id : dumas-02448388, version 1


Joanna Lupo. Arenicola marina : le nouvel espoir marin pour la santé publique. Sciences pharmaceutiques. 2019. ⟨dumas-02448388⟩



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