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Master Thesis

Étude des facteurs pronostiques de l’évolution du handicap chez les patients atteints de sclérose en plaques primaire progressive dans la région Nord-Ouest

Abstract : Background: Primary progressive multiple sclerosis (PPMS) is the rarest form of this disease, but also the most severe one. Nowadays, few treatments have proven their efficiency, and the potential disease progression predictors are not well known. Objective: To study the disease progression predictors of PPMS patients in North-Western France. Methods: The European database EDMUS was used to extract patient’s personal data of Lille, Rouen and Caen centers, in order to identify the predictors of time from disease onset to EDSS 6 with the Kaplan Meier method. Results: 509 patients were included, with a mean age at disease onset of 42 years, 54% of women, and a mean EDSS at diagnosis of 5.1. The presence of clinical relapses was associated with a shorter time to EDSS 6 (p = 0.005). The Pearson correlation coefficients between this time to EDSS 6 and the age at disease onset, the disease duration at diagnosis, and the EDSS at diagnosis were strongly significant (p < 0.001). Conclusion: The presence of clinical relapses, a higher age at disease onset, a shorter disease duration at diagnosis, and a lower EDSS at diagnosis were the main disease progression predictors of PPMS patients in this study. More studies are needed to confirm these results, with a larger number of patients, and with the inclusion of radiological data.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02464527
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Submitted on : Monday, February 3, 2020 - 11:51:28 AM
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Alice Ray. Étude des facteurs pronostiques de l’évolution du handicap chez les patients atteints de sclérose en plaques primaire progressive dans la région Nord-Ouest. Médecine humaine et pathologie. 2019. ⟨dumas-02464527⟩

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