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Master Thesis

Étude du sens d'agentivité dans la dystonie myoclonique

Abstract : Introduction: Agency is underpinned by inferential retrospective and predictive prospective mechanisms. Our hypothesis is based on a preliminary study with cervical dystonia patients: disruption of agency could be associated with dystonia. Aim: To investigate if agency abnormalities in myoclonus dystonia (DYT-SGCE) exist and study their neuronal correlates. Methods: We compared DYT-SGCE patients and healthy volunteers (HV) in a “Magic” task where subjects had to catch targets on a computer screen through different experimental conditions. The “Lag” condition was defined by a subtle visuo-motor disruption. A composite agency score was computed based on judgments of control and judgments of performance in each condition. An implicit measure of agency was also performed with a classic “Libet” task. We performed a VBM analysis of regions of interest to investigate structural neural correlates of agency. Results: 24 DYT-SGCE patients and 25 HV comparable on demographic data (all p < 0.05) were included. In the “Magic” task, in “Lag” condition, patients detected more the loss of control (F1,48 = 26.04, p = 0.004). In the Libet task, there was no difference within groups (all p > 0.05). VBM signal was higher in motor cerebellum in patients group and was negatively correlated with the agency composite score (all p < 0.05). Conclusion: There is abnormalities of sense of agency un myoclonus dystonia. Such disruption could be due to cerebello-thalamic pathway disturbances.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02465022
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  • HAL Id : dumas-02465022, version 1

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Clément Tarrano. Étude du sens d'agentivité dans la dystonie myoclonique. Médecine humaine et pathologie. 2019. ⟨dumas-02465022⟩

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