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Master Thesis

Altérations neurofonctionnelles sous-tendant la régulation émotionnelle, dans la schizophrénie et l’épisode dépressif caractérisé, lien avec l'émoussement affectif : revue systématique de la littérature des études en imagerie par résonance magnétique fonctionnelle

Abstract : Introduction: We hypothesize that different neural correlates underlie the emotional dysregulation in these two diseases. We made a systematic review with studies using functional magnetic resonance imaging (fMRI) that evaluated neuro correlates of emotional dysregulation in SCZ and MDD. Method: We searched on PubMed studies using fMRI interested in emotional regulation of visual stimuli, employing implicit or explicit regulation tasks, from this different keywords: "schizophrenia" "depressive disorder, major" "blunted affect" "emotion processing". Result: Patients with SCZ or MDD, showed different activation dysfunctions in cerebral regions involved in emotional regulation and visual stimuli processing. Functional connectivity was altered in prefronto-limbic network in both SCZ and MDD. Discussion: Different factors were influencing neurofunctional alterations between SCZ and MDD patients: negative symptoms severity in SCZ, and extrinsic factors in MDD. In SCZ, blunted affect was correlated to specific neurofunctional alteration. Conclusion: Different neurofunctional alterations underlie an emotional dysregulation in SCZ and MDD.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02480923
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Camille Delouche. Altérations neurofonctionnelles sous-tendant la régulation émotionnelle, dans la schizophrénie et l’épisode dépressif caractérisé, lien avec l'émoussement affectif : revue systématique de la littérature des études en imagerie par résonance magnétique fonctionnelle. Médecine humaine et pathologie. 2019. ⟨dumas-02480923⟩

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