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Master Thesis

Impact des inhibiteurs de l’enzyme de conversion et des bêtabloquants sur la survenue d’une cardiopathie aux anthracyclines : une étude rétrospective

Abstract : Introduction. Improvement in the prognosis of cancer patients has led to new concerns about anticancer drugs side effects. Whether betablockers (BB) and angiotensin converting enzyme inhibitors (ACE-I) could prevent the anthracycline’s (ATC) cardiotoxicity in patients with lymphoma and high blood pressure (HBP) remains unknown. Materiels and methods. We extracted patients from a hematological regional registry and collected patient’s information thanks to a medical software of the Caen University Hospital. Left ventricle dysfunction (LVD) occurrence was defined by a degradation of the left ventricular ejection fraction (LVEF), either by a LVEF<50% or a degradation of 10% comparatively to the previous LVEF before the chemotherapy. The principal objective was to evaluate the impact of BB and/or ACE-I on LVD development associated to ATC. Results. Among the 1324 patients with LH or LNH, we included 93 patients treated for HBP and having received ATC and with available LVEF. Thirty-five patients developed a DVG (37.6%). Forty one patients had an ACE-I (44.1%), 51 patients a BB (54.8%) and 22 patients an ACEI and a BB (23.7%). There was no significant difference between the two groups (LVD and no LVD) regarding BB (p=0.40), ACE-I (p=0.28) or BB and ACE-I (p=0.13). Conclusion. Among lymphoma patients treated for HBP and having received ATC, BB and ACE-I do not seem to have any protective effect on LVD development.
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Master Thesis
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Margaux Penet. Impact des inhibiteurs de l’enzyme de conversion et des bêtabloquants sur la survenue d’une cardiopathie aux anthracyclines : une étude rétrospective. Médecine humaine et pathologie. 2019. ⟨dumas-02485334⟩

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