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Master Thesis

Particularités cliniques et physiopathologiques de l’atteinte articulaire au cours de la vascularite à IgA chez l’adulte : étude de deux cohortes françaises

Abstract : Introduction: Articular involvement in adult form-IgA vasculitis (IgAV) is a frequent manifestation. The aim of this study was to characterize articular involvement, to identify the clinical and biological phenotype of patients with joints involvement and to understand the physiopathological mechanism of this presentation. Methods: We used data of IGAVAS survey, a French retrospective multicentric cohort, to characterize articular involvement and to compare characteristics of patients with and without joints involvement. We compared cytokine and T-cells concentrations in the plasma using data and samples from HSPrognosis cohort, a French prospective study. Results: Among 260 patients, 160 had articular involvement, mainly arthralgias of knees and ankles, resolving in 96% cases. Those patients were younger (OR=0.87; p=0.0021) and had more gastro-intestinal tract involvements (OR=2.080; p=0.0116). No difference was demonstrated on relapses or survival. Serum interleukin-1β (IL-1β) level was higher in patients with joints involvement. Conclusion: Articular involvement is a frequent manifestation of IgAV in adults, mainly arthralgias of knees and ankles, with favorable evolution. It was associated with a younger age and more frequent gastro-intestinal tract involvements, which conditions short term prognosis. Those patients had a higher serum IL-1β level, suggesting implication of IL-1β in articular involvement physiopathology and the potential interest of Il-1 blocking agents in the treatment.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02490432
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  • HAL Id : dumas-02490432, version 1

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Alice Delapierre. Particularités cliniques et physiopathologiques de l’atteinte articulaire au cours de la vascularite à IgA chez l’adulte : étude de deux cohortes françaises. Médecine humaine et pathologie. 2019. ⟨dumas-02490432⟩

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