Skip to Main content Skip to Navigation
Master Thesis

Prévention et prise en charge du diabète de type 2 chez les patients souffrant de schizophrénie traités par antipsychotiques de seconde génération

Abstract : Since the 80s, second-generation or atypical antipsychotics (SGA) have taken an important place in therapies have led to a reduction in iatrogenic extrapyramidal effects, to the detriment of a greater incidence of obesity, diabetes mellitus (DM) and acidocetotic comas that emerge in a population whose mental pathology effects with SGA prescription in schizophrenia. Adopting individual preventive and curative therapeutic strategies for weight gain (adiposity and insulinoresistance) and DM to reduce the risk of morbi- objectives are considered: (i) the association between SGA prescription and DM. diagnosis, (ii) The pharmacological and non-pharmacological preventive and curative therapeutic strategies of DT2 in patients with schizophrenia and treated with an SGA. The risk of DM is heterogeneous for the different SGA by indirect mechanisms (weight gain) and direct on insulinosecretion. The implementation of HDR must be systematic when prescribing an SGA. The introduction of olanzapine or clozapine, patients with high risk of progression to DM, 7% rapid weight gain, BMI greater than 25 kg/m2 are indications for a 6 months structured intervention. In case of failure, ineffectiveness or impossibility of pharmacological switch, the addition of metformin or topiramate are the two recommended adjuvant treatments. Aripiprazole is also an effective strategy in combination with olanzapine and clozapine
Complete list of metadatas

Cited literature [221 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02498525
Contributor : Médecine Ub <>
Submitted on : Wednesday, March 4, 2020 - 3:14:25 PM
Last modification on : Friday, October 23, 2020 - 4:34:50 PM
Long-term archiving on: : Friday, June 5, 2020 - 2:41:38 PM

File

Med_spe_2020_Grondier-Sorbara....
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02498525, version 1

Collections

Citation

Brian Grondier-Sorbara. Prévention et prise en charge du diabète de type 2 chez les patients souffrant de schizophrénie traités par antipsychotiques de seconde génération. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02498525⟩

Share

Metrics

Record views

128

Files downloads

38