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Master Thesis

Influence de la position et du moment de la journée sur la pression transcutanée en oxygène (TcPO2) chez le sujet sain

Abstract : Introduction: the pathophysiology of restless legs syndrome remains imperfectly known. Some studies suggest an involvement of peripheral hypoxia in the pathophysiology of this disease. We do not know anything about a possible positional or circadian variation of peripheral oxygenation in the healthy subject. Objective: the main objective of the study is to check whether there is, physiologically, a significant variation between TcPO2 when walking and TcPO2 in decubitus, in the healthy subject. If this difference exists, the secondary objective will be to know if it is physiologically more marked or if it does not manifest itself until the end of the day. Patients and methods: non-interventional study (category 3), on healthy volunteers, longitudinal, prospective, unicentric. The collection was carried out in the vascular exploration department of Saint-André hospital in Bordeaux. The study population including men and women aged 18 to 65. Subjects with active smoking or a history of smoking intoxication, type 1 or 2 diabetes, arterial disease of the lower limbs, known pregnancy (without beta-hcg dosage), symptoms of restless legs syndrome in subjects or in the immediate family, an abnormal neurological examination, a known iron deficiency, were excluded from the study. A recording of TcPO2 was carried out while walking, in decubitus, and in a seated position. PSO measurements were carried out simultaneously. These recordings were made at two times of the same day: in the morning and at the end of the day. Results: 16 healthy volunteers were included in the study. 1 subject was excluded from the study. There is a significant difference between TcPO2 in decubitus and walking and this twice: in the morning (p = 0.00068) and in the evening (p = 0.00072) Discussion / conclusion: our results suggest that, in healthy subjects, there is a physiological difference between TcPO2 in decubitus and walking. We have highlighted this variation twice: in the morning and at the end of the day. On the other hand, we did not observe any difference between the morning and evening TcPO2 regardless of the position. Our data support an improvement in peripheral oxygenation when walking in healthy subjects. The fact that walking relieves RLS symptoms and improves tissue oxygenation may suggest an involvement of peripheral hypoxia in the pathophysiology of restless legs syndrome. The involvement of peripheral hypoxia in RLS could offer new perspectives in the management and treatment of this condition.
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Master Thesis
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Submitted on : Monday, March 30, 2020 - 5:11:41 PM
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Sofian Benzekri. Influence de la position et du moment de la journée sur la pression transcutanée en oxygène (TcPO2) chez le sujet sain. Médecine humaine et pathologie. 2020. ⟨dumas-02525056⟩

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