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Master Thesis

Évaluation de la vaccination anti-pneumococcique chez les immunodéprimés dans un service d’hôpital de jour de médecine interne et de maladie vasculaire

Abstract : Introduction: pneumococcal infections are frequent and potentially serious in patients with inflammatory diseases especially autoimmune immunosuppressed. This population of patients considered at very high risk of infection is subject to national vaccine recommendations. The main objective of this work was to evaluate the pneumococcal vaccination coverage in a day hospital (internal medicine and vascular diseases) of the University Hospital of Bordeaux in patients treated with immunosuppressants. Methods: we carried out an observational, descriptive, retrospective and monocentric study. We included 150 patients over a period of 3 months (February to April 2018). We studied the pneumococcal vaccine coverage and the time elapsed between the date of vaccination with the 13-valent vaccine (PCV13) and the start of initial treatment in order to estimate the vaccine efficacy according to the treatment used according to the national recommendations of the High Authority of Health. Results: of the 150 patients included in the study with an indication for pneumococcal vaccination, PCV13 vaccination coverage was 84% and decreased to 51% for the complete vaccine regimen. After adjusting the vaccine efficacy according to the date of introduction of the treatment only 31% of the cohort was able to benefit from an optimal complete vaccine regimen on our study. The results are discussed with the most recent literature results. Conclusion: in line with current studies, immunization coverage against pneumococcus remains insufficient in this population of patients treated with immunosuppressive therapies. Improving our practices requires finding solutions. In our opinion, there is a way to improve, beyond the training of the prescribers, the implementation of a help with the computerized prescription of the vaccination and the surveillance of the vaccination scheme in a more optimal way.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02530258
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Thursday, April 2, 2020 - 6:38:39 PM
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Alexandre Voignier. Évaluation de la vaccination anti-pneumococcique chez les immunodéprimés dans un service d’hôpital de jour de médecine interne et de maladie vasculaire. Médecine humaine et pathologie. 2020. ⟨dumas-02530258⟩

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