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Master Thesis

Utilité pronostique de la [18F] fluorodeoxyglucose tomographie par émission de positon/tomodensitométrie pré transplantation chez les patients atteints d’un lymphome B diffus à grandes cellules traités par rituximab, dexamethasone, cytarabine à haute dose, carboplatine en chimiothérapie de sauvetage

Abstract : We analysed the outcomes of 62 patients with refractory/relapsed diffuse large B‐cell lymphoma (rrDLBCL) who had pre‐transplantation fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) after R‐DHAC (rituximab, dexamethasone, high‐dose cytarabine, carboplatin) salvage chemotherapy, and were evaluated using Deauville criteria and total lesion glycolysis (TLG). A positive pre‐transplantation PET/CT with Deauville score of 5 was associated with shorter progression‐free survival (PFS) (P = 0·01), while a Deauville score of 4 was not predictive of outcome. Only pre‐transplant TLG was significantly associated with both PFS (P = 0·005) and overall survival (P = 0·03). TLG deserves to be further investigated in prospective studies.
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https://dumas.ccsd.cnrs.fr/dumas-02558538
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Submitted on : Wednesday, April 29, 2020 - 4:45:24 PM
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Alexandre Roch. Utilité pronostique de la [18F] fluorodeoxyglucose tomographie par émission de positon/tomodensitométrie pré transplantation chez les patients atteints d’un lymphome B diffus à grandes cellules traités par rituximab, dexamethasone, cytarabine à haute dose, carboplatine en chimiothérapie de sauvetage. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02558538⟩

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