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Master Thesis

Neurodevelopmental outcome at 2 years old for children born before 29 gestational weeks at Grenoble hospital

Abstract : Introduction: Very preterm children are at a high risk for neurological impairment, especially those with bronchopulmonary dysplasia (BPD). The main goal of this study is to assess neurodevelopmental outcomes for 2 years of corrected age children born before 29 weeks’ Gestational Age (wGA) between 2010 and 2015 and affected with BPD at 28 days of life, and look for risk factors. Material and methods: This was a retrospective cohort about children hospitalised in the university hospital in Grenoble, born before 29 wGA between 2010 and 2015, included in the monitoring network Naitre et Devenir (RND). Non-optimal neurodevelopmental outcome at 2 years corrected age was defined with a global developmental quotient (DQ) at the revisited Brunet-Lézine scale < 85, blindness, deafness, or cerebral palsy (CP) ≥ 3 over five levels according to the Gross Motor Function Classification System. Results: One hundred and nineteen children were included and 99 were monitored at age 2 years: 31.3% of the population had non-optimal neurodevelopment. 4% of whom had CP. The median DQ test was 90 (interquartile 82 -97). Factors associated with non-optimal neurodevelopment in univariate analysis were low gestational age, low birth weight, a cord pH < 7.2, chorioamnionitis, a treatment of persistent ductus arteriosus and a longer oxygenotherapy. In multivariate analysis, low birth weight and chorioamnionitis remained significatives. 14.7% of the hospitalised children were treated with PNS as betamethasone. PNS was not associated with a non-optimal neurological outcome. Conclusion: In a population of very preterm children, one third had a non-optimal neurological outcome at 2 years of corrected age.
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Master Thesis
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Submitted on : Monday, May 25, 2020 - 9:51:31 AM
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Léa Decollogne. Neurodevelopmental outcome at 2 years old for children born before 29 gestational weeks at Grenoble hospital. Human health and pathology. 2020. ⟨dumas-02572438⟩



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