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Master Thesis

Facteurs distinctifs entre leptospirose et dengue à la prise en charge initiale hospitalière en contexte endémo-épidémique

Abstract : Background: leptospirosis is a potentially serious disease but can be easily confused with dengue fever (DF). Hence, there is a risk of delayed diagnosis and delayed antibiotic treatment initiation which can potentially promote the progression to severe forms. Objective: identifying predictive factors for the diagnosis of leptospirosis compared to dengue fever. Methods: case-control study comparing confirmed leptospirosis to DF cases at hospital admittance using bivariate and multivariate analysis. Results: one hundred leptospirosis and 201 DF cases were included. In multivariate analysis, the most discriminating parameter was CRP for which a threshold of 50 mg/L, had a sensitivity of 94% (95%CI: 0.88−0.97) and specificity of 95% (95%CI: 0.92−0.98). The positive and negative likelihood ratio was respectively 21 (95%CI: 11−40) and 0.06 (IC95:0.03−0.14). Conclusion: CRP is a quick and reliable orientation test to help distinguish leptospirosis from dengue fever.
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https://dumas.ccsd.cnrs.fr/dumas-02863769
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Submitted on : Wednesday, June 10, 2020 - 3:31:32 PM
Last modification on : Saturday, June 13, 2020 - 3:18:28 AM

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David Hirschinger. Facteurs distinctifs entre leptospirose et dengue à la prise en charge initiale hospitalière en contexte endémo-épidémique. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02863769⟩

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