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Master Thesis

Étude de l’effet de la curcumine sur des bactéries impliquées dans la maladie parodontale

Abstract : Curcumin is a natural polyphenol identified as responsible of most of the therapeutic properties of interest usually associated with turmeric : antioxidant, anti-inflammatory, anticancer, antibacterial, antifongal and wound healing. These properties could be used in periodontal treatment. The aim of this study is to showcase a simplified procedure putting the in vitro experiment closer to a practical clinical procedure and to compare curcumin’s antibacterial potential to the chlorhexidin’s one on Fusobacterium nucleatum, Porphyromonas gingivalis, Tanerella forsythia and Aggregatibacter actinomycetemcomitans which are associated with periodontal disease. The inhibition diameters obtained by applying paper disks soaked in several concentrations of curcumin solutions on the bacterial cultures are compared to those obtained with the same concentrations of chlorhexidin and to reference solution of 2% chlorhexidin. The results obtained are not in favor of the use of curcumin as an alternative to chlorhexidine in periodontology or at least not with comparable ease of implementation. Other studies are to be carried out in order to specify the results obtained and to consider other protocols.
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https://dumas.ccsd.cnrs.fr/dumas-02887665
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Arnaud Cadet. Étude de l’effet de la curcumine sur des bactéries impliquées dans la maladie parodontale. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02887665⟩

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