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Master Thesis

Étude de la séroprévalence et de l’incidence du virus de l’hépatite E chez des homosexuels masculins sous prophylaxie pré-exposition contre le VIH

Abstract : Objectives: To investigate the seroprevalence and incidence of hepatitis E virus (HEV) infection in men who have sex with men (MSM) who have been exposed to pre-exposure prophylaxis (PrEP) against HIV as sexual transmission of HEV has been suggested. Methods: A total of 147 PrEP-using MSM and 147 blood donors matched for sex, age and geographical area were tested for anti-HEV IgG and IgM. Among them, 135 have been followed for 1 year, at the end of which serological tests for HEV were performed. Laboratory data on sexual transmitted infections (STIs) and viral hepatitis, including hepatitis A virus (HAV), were collected. Results: Baseline seroprevalence rates in PrEP users were 42.2% (anti-HEV IgG) and 3.4% (anti-HEV IgM). Those of the control blood donors were similar (anti-HEV IgG 43.5% and anti-HEV IgM 4.1%). There was no incident of HEV infection despite the rates of bacterial STIs (incidence rate (IR) = 46.6%) and HAV infection (IR=15.8%). Age was the only risk factor associated with anti-HEV IgG seropositivity at baseline and at the end of follow-up. Conclusion: Sexual transmission is not a major route of HEV infection in MSM, unlike HAV.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02935355
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Submitted on : Thursday, September 10, 2020 - 11:50:34 AM
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Marion Migueres. Étude de la séroprévalence et de l’incidence du virus de l’hépatite E chez des homosexuels masculins sous prophylaxie pré-exposition contre le VIH. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02935355⟩

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