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Master Thesis

Recherche d’une solution aux défaillances de vide de ligne dans le secteur du conditionnement

Abstract : Manufacture of medicines ends with the essential stage of packaging. This step provides a labelled finished product accompanied by all the information necessary to allow correct administration by the patient. To ensure quality and traceability of these medicines, pharmaceutical industries must notably respect a Good Manufacturing Practices (GMP) requirement: line clearance. This operation takes place at the end of each batch and consists in verifying that the packaging line is empty of all elements not necessary for the next batch. This critical operation is manual and complex. Therefore, many line clearances failures occur within industries. Depending on the case, these failures represent a higher or lower risk for the product quality and for the patient. Their cause is generally multifactorial : there are often several causes or contributing factors, which complicates the resolution of the problem. This thesis exposes the search for a solution to this global problem of line clearance failures. Analysis of potential causes leads to several solutions. First, a solution is based on the implementation of an activity associated with line clearance called Live Line Clearance (LLC). This activity allows, through the positioning of test elements on the packaging line at each line clearance, to monitor this activity’s performance and to maintain operator’s attention. This activity can also be arranged and thus represent other solutions. Finally, a solution is based on the use of new technologies, virtual and augmented realities. These can be applied to training as well as to the line clearance execution and represent two promising tracks.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02938038
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Submitted on : Monday, September 14, 2020 - 4:18:38 PM
Last modification on : Wednesday, October 14, 2020 - 3:50:10 AM

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Caroline Billiaux. Recherche d’une solution aux défaillances de vide de ligne dans le secteur du conditionnement. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02938038⟩

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