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Master Thesis

La comorbidité dépressive chez les sujets épileptiques: une revue non-exhaustive de la littérature

Abstract : Epilepsy is one of the most common neurologic conditions affecting around 50 million people around the world. Half of these individuals suffer from psychiatric comorbidity and depression is the most common psychiatric comorbid disorder. This non-exhaustive literature review aims to draw a picture of the current state of knowledge pertaining to this comorbidity epidemiology and set out new leads for its detection and treatment. For the purposes of this study, international publications made public on the PubMed database between 2000 and 2019 were reviewed. Data extracted from this sample suggests that depression is affecting between 7.1% and 85.3% of epileptic individuals resulting in an average prevalence of depression amounting to 28.4%. Several socio-demographic, clinical or treatment-related factors have been found to increase the risk of suffering from depression. Depressive comorbidity has an important functional impact: it affects the quality of life of epileptic individuals, diminishes their observance of and tolerance to anti-epileptic treatments and aggravates their medical prognostic by increasing both their resistance to treatment and suicidal risk. Despite these well-known effects, depression remains an under-diagnosed and under-treated comorbidity. A specific self-questionnaire named NDDI-E allows for the detection of depressive symptoms in epileptic individuals and should be systematically used for each new diagnosis and then once a year for the neurological monitoring of the individual. When depression is evidenced, a pharmacologic treatment might become necessary. Selective serotonin reuptake inhibitors, such as escitalopram and citalopram should be given priority. Their combination with non-pharmacological interventions such as cognitive-behavioral therapy may also be considered.
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Submitted on : Wednesday, September 23, 2020 - 1:29:39 PM
Last modification on : Friday, October 30, 2020 - 12:05:21 PM
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  • HAL Id : dumas-02946733, version 1



Julia Tourenne-Violeau. La comorbidité dépressive chez les sujets épileptiques: une revue non-exhaustive de la littérature. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02946733⟩



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